Chemoenzymatic glycan editing for boosting the efficacy of cell-based cancer immunotherapy

Session: 
S8.1 Glycans in cancer
Code: 
KL8.1
Location (hall): 
Glucose
Start/end time: 
Thursday, July 4, 2019 - 11:15 to 11:45
Speaker reference: 
Peng
Wu

Peng Wu1

1The Scripps Research Institute, La Jolla, United States

Cancers, such as breast and colon cancer, are chronical diseases that affect millions of people worldwide. Adoptive cell transfer-based therapies have received lots of attention in recent years for treating various types of cancers. Kymriah, a chimeric antigen receptor T-cell (CAR-T) therapy that was approved recently as the first cell-based gene therapy in the United States, is a preeminent example. However, in the tumor microenvironment has evolved numerous strategies to downregulate the cytotoxicity of the transferred T cells. In this talk, I will describe a strategy that is based on chemoenzymatic editing of cell-surface glycans to boost the efficacy of cell-based immunotherapy. 

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