Synthesis of oligosaccharides representative of plant cell wall glycans

S2.1 Oligosaccharide synthesis I
Location (hall): 
Start/end time: 
Monday, July 1, 2019 - 14:15 to 14:45
Speaker reference: 

Mads Clausen1

1Center for Nanomedicine and Theranostics, DTU Chemistry, Kgs. Lyngby, Denmark

Plant cell walls are structurally complex and contain a large number of diverse carbohydrate polymers. These plant fibers are a highly valuable bio-resource and the focus of food, energy and health research. We are interested in studying the interplay of plant cell wall carbohydrates with proteins such as enzymes, cell surface lectins, and antibodies. However, detailed molecular level investigations of such interactions are hampered by the heterogeneity and diversity of the polymers of interest. To circumvent this, we target well-defined oligosaccharides with representative structures that can be used for characterizing protein-carbohydrate binding. The presentation will highlight chemical syntheses of plant cell wall oligosaccharides from the group and provide examples of their interactions with proteins.

Figure 1. Examples of current synthetic targets