New 3D printable glyco-biomaterials: synthesis and characterization of scaffolds for advanced 3D organoids and in vitro models

S10.4 Carbohydrate materials
Location (hall): 
Start/end time: 
Thursday, July 4, 2019 - 17:15 to 17:30

Laura Russo1, Sofia Magli1, Susanna Sampaolesi1, Linda Rabbachin1, Giulia Risi2, Cesare Cosentino2, Sabrina Bertini2, Francesco Nicotra1

1University of Milano-Bicocca, Milan, Italy, 2Ronzoni Institute for Chemical and Biochemical Research, Milan, Italy

Glycans are modulators of cell-cell and cell-Extracellular matrix (ECM) interactions. The ability to mimic the structural and biochemical role of ECM is one of the way to control specific cell fates, inducing the formation of functional tissues. Both, physical and biochemical motifs of ECM can be employed in order to stimulate organoids formation or tissue constructs. A wide variety of glycans (polysaccharides, glycoproteins and proteoglycans) are involved in cell - microenvironment interactions and finely tune cell fate in physiological and pathological states. Three-dimensional (3D) cell cultures have recently gained attention based on their potential to recapitulate tissue physiology and functions. 3D scaffold supports, cell aggregate systems and hydrogels are good candidates to support the formation of functional tissues and organoids for studying the effects of drugs and bioactive agents on 3D in vitro models. The design of new hybrid glycopolymers that can be formulated as scaffolds or bioprintable materials is of interest in the development of new materials employable in 3D functional in vitro constructs. Herein we present the design, the synthesis and the characterization of new hybrids bioprintable Glycobiomaterials and their evaluation for advanced 3D in vitro cell models.

GlycoBiomaterials for in vitro 3D in vitro models