Synthetic carbohydrate-based materials

<none>

Programme Social programme Plenary speakers Keynote speakers 1st EuroCarb Young Researcher (ECYR) Workshop CarboMet Workshop Mini symposium: Glycobiology at the LUMC and beyond Favourites/Agenda

Social programme

Plenary speakers

Keynote speakers

1st EuroCarb Young Researcher (ECYR) Workshop

CarboMet Workshop

Mini symposium: Glycobiology at the LUMC and beyond

Favourites/Agenda

Photos

Venue & Travel Venue Accommodation City of Leiden Travel directions

Venue

Accommodation

City of Leiden

Travel directions

Committees

Home

Synthetic carbohydrate-based materials

Yang Yu 1 , Soeun Gim 1 , Peter H. Seeberger 1 , Martina Delbianco 1

1 Max Planck Institute of Colloids and Interfaces, Potsdam, Germany

Polysaccharides are the most abundant organic materials in nature, yet correlations between their three-dimensional structure and macroscopic properties have not been established. Automated glycan assembly (AGA) enables the preparation of well-defined oligo- and polysaccharides resembling natural as well as unnatural structures [1]. A collection of related compounds, modified at specific positions of the chain, is presented (Fig1). These synthetic glycans are ideal probes for the fundamental study of polysaccharides, shedding light on how the modification patterns affect the polysaccharides properties (i.e. three dimensional shape). Molecular modelling simulations and NMR analysis show that different classes of polysaccharides adopt fundamentally different conformations, drastically altered by single-site substitutions [2].

Moreover, these synthetic oligosaccharides are shown to self-assemble into nanostructures of varying morphologies. Well-defined differences in chain length, monomer modification, and aggregation methods yield glycomaterials with distinct shapes and properties. These novel synthetic materials show unexpected excitation-dependent optical properties in a broad range within the visible spectrum, illustrating their potential for use in optical devices and imaging applications.

Synthetic cellulose oligomers with different modification patterns. Molecular dynamic simulations and oligosaccharide-based nanoparticles (NPs).

A. Pardo-Vargas, M. Delbianco, P.H. Seeberger, Curr. Opin. Chem. Biol., 2018, 46, 48 [2] M. Delbianco, A. Kononov, A. Poveda, Y. Yu, T. Diercks, J. Jiménez-Barbero, P. H. Seeberger, J. Am. Chem. Soc. 2018, 140 (16), 5421.

Contact eurocarb@eurocarb2019.com for general questions about EUROCARB2019, or codee@eurocarb2019.com for scientific questions.

Leiden University / Leiden Institute of Chemistry lic.leidenuniv.nl

European Carbohydrate Organisation

Congress by Design www.congressbydesign.com