Strategies for the development of n-glycomimetics

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1st EuroCarb Young Researcher (ECYR) Workshop

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Mini symposium: Glycobiology at the LUMC and beyond

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Strategies for the development of n-glycomimetics

Niels-Christian Reichardt 1 , Anna Cioce 1 , Franck Fieschi 2

1 CIC BiomaGUNE, San Sebastian, Spain, 2 Université Grenoble Alpes, CEA, CNRS, IBS, Grenoble, France

A growing number of studies including glycan array binding assays illustrate how larger oligosaccharides are bound by lectins with far higher affinity than smaller fragments or monosaccharides. Oligosaccharide ligands presented with a defined surface density can give rise to very selective binding events on cell surfaces. Based on the hypothesis that complex N-glycans can engage in multiple interactions with carbohydrate binding proteins that exceed binding to the primary lectin binding site, we have developed strategies for the synthesis of N-glycomimetics as high affinity lectin targeting probes and inhibitors. Here I present the results of our on-chip and solution phase synthesis of a library of N-glycan mimetics and initial binding assays with plant and human C-type lectins.

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