Synthesis of microbial sialic acids for the study of their glycobiology

<none>

Programme Social programme Plenary speakers Keynote speakers 1st EuroCarb Young Researcher (ECYR) Workshop CarboMet Workshop Mini symposium: Glycobiology at the LUMC and beyond Favourites/Agenda

Social programme

Plenary speakers

Keynote speakers

1st EuroCarb Young Researcher (ECYR) Workshop

CarboMet Workshop

Mini symposium: Glycobiology at the LUMC and beyond

Favourites/Agenda

Photos

Venue & Travel Venue Accommodation City of Leiden Travel directions

Venue

Accommodation

City of Leiden

Travel directions

Committees

Home

Synthesis of microbial sialic acids for the study of their glycobiology

Xianke Meng 1 , Tom Wennekes 1 , Geert-Jan Boons 1

1 Department of Chemical Biology and Drug Discovery, Bijvoet Center for Biomolecular Research, and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands

Pseudaminic acid (Pse) and Legionaminic acid (Leg) are nine-carbon diamino α-ketone monosaccharides that are found as important terminal components of cell surface glycoconjugates in various human-associated microbes such as C. jejuni and M. smithii. However, the exact biological roles of Pse and Leg are not yet fully understood and research in this area is constrained by the difficulties in obtaining Pse and Leg. To further explore their glycobiological significance, we have developed a robust synthesis route for Pse and its derivatives that allows for modifications to create molecular probe derivatives that will allow investigation of its microbial glycobiology. Moreover, we also modified a previously reported synthesis of Leg[1] to create probes that allow for metabolic labeling of Leg.

The synthesis overview of Pseudaminic acid and Legionaminic acid.

Santra, A.; Xiao, A.; Yu, H.; li, W.; Li, Y.; Ngo, N.; McArthur, J. B.; Chen, X. Angew. Chem., Int. Ed. 2018, 57, 2929– 2933.

Contact eurocarb@eurocarb2019.com for general questions about EUROCARB2019, or codee@eurocarb2019.com for scientific questions.

Leiden University / Leiden Institute of Chemistry lic.leidenuniv.nl

European Carbohydrate Organisation

Congress by Design www.congressbydesign.com