Glycosyl chlorides are useful donors and precursors in oligosaccharide synthesis. Commonly used methods for synthesis of glycosyl chlorides from hemiacetals require stoichiometric amounts of reagents, additional additives or heating.[1,2] Herein, we report a new method to synthesise glycosyl chlorides using catalytic Appel conditions.[3,4] Triphenylphosphine oxide, which is generally a stoichiometric waste product in conventional Appel reactions, is used as a catalyst in our method (Scheme 1).
We will also describe our efforts to develop a one-pot glycosylation via the interception of the alkoxyphosphonium intermediate.
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