The Synthesis and Biological Evaluation of Mincle Ligands as Potential Vaccine Adjuvants

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1st EuroCarb Young Researcher (ECYR) Workshop

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Mini symposium: Glycobiology at the LUMC and beyond

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The Synthesis and Biological Evaluation of Mincle Ligands as Potential Vaccine Adjuvants

Thomas Teunissen 1 , Mattie Timmer 1 , Bridget Stocker 1

1 Victoria University Of Wellington, Wellington, New Zealand

In recent years, there has been much interest in harnessing the potential of bacterial glycolipids as vaccine adjuvants due to their ability to induce a strong Th-1 immune response. These molecules can be recognized by pattern recognition receptors (PRR) that are expressed by many cells of the immune system. Macrophage inducible C-type lectin (Mincle) is one such PRR that can recognize a wide range of molecules including both damage-associated and pathogen-associated molecular patterns.[1] Many studies have focussed on determining the scope of ligands that bind Mincle and how structural modifications to these ligands influence their immune response. In particular, trehalose glycolipids represent a potent class of promising Mincle agonists.[2] To this end, we sought to investigate how changes to the trehalose glycolipid structure influences Mincle agonistic activity, with a view that the findings could lead to the development of improved vaccine adjuvants.

X. Lu, M. Nagata, S. Yamasaki. Mincle: 20 years of a versatile sensor of insults. Int. Immunol. 30, 6, 2018, 233–239.

C. D. Braganza, T. Teunissen, M.S.M. Timmer, B.L. Stocker. Identification and Biological Activity of Synthetic Macrophage Inducible C-Type Lectin Ligands. Front. Immunol. 2018, 8, 1940.

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