Ianhtitle: Synthesis of Ribosyl-Ribosyl-Adenosine Trisphosphate the Branched Portion of Poly-ADP-Ribose

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Ianhtitle: Synthesis of Ribosyl-Ribosyl-Adenosine Trisphosphate the Branched Portion of Poly-ADP-Ribose

Qiang Liu 1 , Hermen Overkleeft 1 , Gijs van der Marel 1 , Dmitri Filippov 1

1 Bioorganic synthesis, Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands

Poly-adenosine diphosphate ribose (poly-ADPr) is an important biopolymer which is synthesized by poly-ADPr polymerases (PARPs) and occurs as a post-translational modification of various proteins and enzymes. ADPr-chains can be either linear or branched. Although the involvement of ADPr in many cellular processes has become clear over the past decades, the mechanism of its action and in particular the role of branched ADPr structures in the signaling events remains elusive. Synthetic well-defined structures are essential to get a better understanding of the function of branched ADPr at the molecular level. In this project, we aim to develop a synthetic methodology towards branched ADPr chains.

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