Ianhtitle: Synthesis of Ribosyl-Ribosyl-Adenosine Trisphosphate the Branched Portion of Poly-ADP-Ribose

PS1 Poster session 1 Odd numbers
Location (hall): 
Start/end time: 
Monday, July 1, 2019 - 15:45 to 17:15

Qiang Liu1, Hermen Overkleeft1, Gijs van der Marel1, Dmitri Filippov1

1Bioorganic synthesis, Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands

Poly-adenosine diphosphate ribose (poly-ADPr) is an important biopolymer which is synthesized by poly-ADPr polymerases (PARPs) and occurs as a post-translational modification of various proteins and enzymes. ADPr-chains can be either linear or branched. Although the involvement of ADPr in many cellular processes has become clear over the past decades, the mechanism of its action and in particular the role of branched ADPr structures in the signaling events remains elusive. Synthetic well-defined structures are essential to get a better understanding of the function of branched ADPr at the molecular level. In this project, we aim to develop a synthetic methodology towards branched ADPr chains.