DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Nonintegrin; CD209 antigen), a lectin present mainly on the surface of dendritic cells plays a relevant role in the efficacy of the immune system. This lectin strongly interacts with highly mannosylated and fucosylated cell membranes of some pathogens leading to internalization into the dendritic cell. Many research groups have devoted their efforts in recent years to the development of highly glycosylated structures targeting DC-SIGN.
We validated a unique synthesis of highly glycosylated dendrimers built from a amino acid derived from methyl glucoside and activity of final conjugates for DC-sign CBL were measured with the Biacore technique and a strong cooperatively of the sugars was found .
- Cattiaux, L.; Porkolab, V.; Fieschi, F.; Mallet, J-M. New branched amino acids for high affinity dendrimeric DC-SIGN ligands. Bioorg. Med. Chem. 2018, 26, 1006-1015.