Oligomannose glycans are among the major targets on the Gp120 component of the HIV envelope protein (Env) for broadly neutralizing antibodies (bnAbs). In 2017 our group designed and synthesized a library of oligomannose mimetics, based on the unique chemical structure of a recently identified bacterial lipooligosaccharide. For every compounds both anomers were synthetized in order to understand which compound provided the best immunoresponse.
One of these mimetics (I) is bound avidly by members of a family of oligomannose-specific bnAbs and their putative common germline precursor when presented as a glycoconjugate1.
- Pantophlet, R.; Lu, N.; Chau, D.; Rempel, C.; Pantophlet, R.; Pantophlet, R.; Trattnig, N.; Kosma, P.; Murrell, S.; Wilson, I. A.; Murrell, S.; Wilson, I. A.; Wilson, I. A.; Wilson, I. A., Nat Commun 2017, 8 (1), 1601.
- Crich, D.; Smith, M., J. Am. Chem. Soc. 2001, 123 (37), 9015-9020.