Model Membranes to Mimic Cellular Environments in Carbohydrate Recognition Processes

<none>

Programme Social programme Plenary speakers Keynote speakers 1st EuroCarb Young Researcher (ECYR) Workshop CarboMet Workshop Mini symposium: Glycobiology at the LUMC and beyond Favourites/Agenda

Social programme

Plenary speakers

Keynote speakers

1st EuroCarb Young Researcher (ECYR) Workshop

CarboMet Workshop

Mini symposium: Glycobiology at the LUMC and beyond

Favourites/Agenda

Photos

Venue & Travel Venue Accommodation City of Leiden Travel directions

Venue

Accommodation

City of Leiden

Travel directions

Committees

Home

Model Membranes to Mimic Cellular Environments in Carbohydrate Recognition Processes

Marta G. Lete 1 , Ana Ardá 1 , Jesús Jiménez-Barbero 1,2

1 CICbioGUNE, Derio, Spain, 2 Basque Foundation for Science (IKERBASQUE), Bilbao, Spain

Molecular recognition by specific targets is at the heart of the life processes. Interactions between proteins and carbohydrates mediate a broad range of biological activities, from embryogenesis to pathological processes. The elucidation of the mechanisms that govern how sugars are accommodated in the binding sites of these receptors is currently a topic of interest. Thus, the determination of structural and conformational factors and physicochemical features which govern the molecular recognition process is of paramount importance.¹ We aim at mimicking the cellular environment using different probes², by performing in vitro experiments,³ and using NMR methods in solution⁴ and in cell, and also under experimental conditions that mimic the cell environment, developing synthetic membranes and exploiting highly crowded atmospheres.⁵ We herein present our preliminary results of the structural details of the interactions between human galectin-3¹ ⁶ with GM3-containing model membranes using NMR spectroscopy.

Gimeno, A. et al. Angew. Chem. Int. Ed. 2019, doi: 10.1002/anie.201900723.

Rahkila J. et al. ChemBioChem. 2019, 20, 203.

Gimeno, A. et al. ACS Chem Biol. 2017, 12, 1104.

Arda, A and Jimenez-Barbero J. Chem. Commun 2018, 54, 5761.

Diniz, A. et al. Chem. Eur. J. 2017, 23, 13213.

Santarsia S. et al. ChemMedChem. 2018, 13, 2030.

Contact eurocarb@eurocarb2019.com for general questions about EUROCARB2019, or codee@eurocarb2019.com for scientific questions.

Leiden University / Leiden Institute of Chemistry lic.leidenuniv.nl

European Carbohydrate Organisation

Congress by Design www.congressbydesign.com