New Unnatural Gallotannins: Synthesis and Evaluation of Biological Activity Using Various In Vitro Assays

Session: 
PS2 Poster session 2 Even numbers
Code: 
P98
Location (hall): 
Foyer
Start/end time: 
Tuesday, July 2, 2019 - 15:45 to 17:15
Zuzana
Hricoviniova

Jana Hricoviniova1, Andrea Sevcovicova2Zuzana Hricoviniova3

1Cancer Research Institute, Slovak Academy of Sciences, Bratislava, Slovakia, 2Faculty of Natural Sciences, Comenius University , Bratislava, Slovakia, 3Institute of Chemistry, Slovak Academy of Sciences, Bratislava, Slovakia

The therapeutic potential of natural antioxidants is a source of inspiration for design of new biologically active structures. Polyphenolic compounds have gained a lot of importance because of their therapeutic and prophylactic potential [1]. Among various naturally occurring polyphenols, hydrolysable tannins represent a large group of strong antiradical and anticancer agents. The molecular structures of gallotannins are basically composed of a central carbohydrate core and gallic acid [2]. Due to their structural diversity and broad array of biological activities have great potential for the development of new pharmaceutically active compounds. Among various naturally occurring gallotannins, penta-1,2,3,4,6-O-galloyl-D-glucose (PGG) was the most widely studied [3]. 

Presented research has been directed towards the synthesis and biological activity evaluation of new, unnatural PGG-analogues. The aim of this study was to investigate the physico-chemical and biological properties of three structurally different gallotannins derived from D-glucose, D-mannose and L-rhamnose. Evaluation of the free radical scavenging activity (DPPH assay, reducing power assay) and their ability to prevent DNA damage (DNA topology assay) will be discussed in our contribution.

References: 
  1. Manach, C., Scalbert, A., Morand, C., Remesy, C., Jimenez, L., Am. J. Clin. Nutr. 2004, 79, 727–747.
  2. Khanbabaee, K., van Ree, T. Nat. Prod. Rep. 2001, 18, 641–649. 
  3. Cao, Y., Himmeldirk, K. B., Qian, Y., Ren, Y., Malki, A., Chen, X., J. Nat. Med., 2014, 68, 465–472.

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