New Unnatural Gallotannins: Synthesis and Evaluation of Biological Activity Using Various In Vitro Assays

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New Unnatural Gallotannins: Synthesis and Evaluation of Biological Activity Using Various In Vitro Assays

Jana Hricoviniova 1 , Andrea Sevcovicova 2 , Zuzana Hricoviniova 3

1 Cancer Research Institute, Slovak Academy of Sciences, Bratislava, Slovakia, 2 Faculty of Natural Sciences, Comenius University , Bratislava, Slovakia, 3 Institute of Chemistry, Slovak Academy of Sciences, Bratislava, Slovakia

The therapeutic potential of natural antioxidants is a source of inspiration for design of new biologically active structures. Polyphenolic compounds have gained a lot of importance because of their therapeutic and prophylactic potential [1]. Among various naturally occurring polyphenols, hydrolysable tannins represent a large group of strong antiradical and anticancer agents. The molecular structures of gallotannins are basically composed of a central carbohydrate core and gallic acid [2]. Due to their structural diversity and broad array of biological activities have great potential for the development of new pharmaceutically active compounds. Among various naturally occurring gallotannins, penta-1,2,3,4,6-O-galloyl-D-glucose (PGG) was the most widely studied [3].

Presented research has been directed towards the synthesis and biological activity evaluation of new, unnatural PGG-analogues. The aim of this study was to investigate the physico-chemical and biological properties of three structurally different gallotannins derived from D-glucose, D-mannose and L-rhamnose. Evaluation of the free radical scavenging activity (DPPH assay, reducing power assay) and their ability to prevent DNA damage (DNA topology assay) will be discussed in our contribution.

Manach, C., Scalbert, A., Morand, C., Remesy, C., Jimenez, L., Am. J. Clin. Nutr. 2004, 79, 727–747.

Khanbabaee, K., van Ree, T. Nat. Prod. Rep. 2001, 18, 641–649.

Cao, Y., Himmeldirk, K. B., Qian, Y., Ren, Y., Malki, A., Chen, X., J. Nat. Med., 2014, 68, 465–472.

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